Free Radicals in the Thermally Sterilized Aminoglycoside Antibiotics
نویسندگان
چکیده
منابع مشابه
Aminoglycoside Antibiotics
Aminoglycosides are hydrophilic, polycationic, aminecontaining carbohydrates that are usually composed of three to five rings. Most aminoglycosides are either natural products or derivatives of soil actinomycetes. They are often secreted by these actinomycetes as mixtures of closely related compounds. The polycationic aminoglycoside chemical structure results in a binding both to the anionic ou...
متن کاملEpr Studies of Thermally Sterilized Vaselinum Album.
Electron paramagnetic resonance (EPR) spectroscopy was used for examination of free radicals in thermally treated vaselinum album (VA). Thermal treatment in hot air as sterilization process was tested. Conditions of thermal sterilization were chosen according to the pharmaceutical norms. Vaselinum album was heated at the following conditions (T--temperature, t--time): T = 160°C and t = 120 min,...
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Thermal formation of free radicals in flumetasone sterilized according to the pharmaceutical norms at 160, 170 and 180 °C was examined by electron paramagnetic resonance (EPR) spectroscopy. The microbiological analysis was done. Similar free radical concentrations were measured for flumetasone sterilized at 160 and 170 °C. The concentration was considerably higher than that for flumetasone ster...
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RNA molecules have key roles in many essential biological processes, including protein synthesis, transcriptional regulation, mRNA splicing and retroviral replication. The structural diversity of RNA, together with the lack of known RNA repair mechanisms, make RNA a challenging and important target for therapeutic intervention [1]. Our understanding of the modes by which RNA is recognized by li...
متن کاملDNA-Aptamers Binding Aminoglycoside Antibiotics
Aptamers are short, single stranded DNA or RNA oligonucleotides that are able to bind specifically and with high affinity to their non-nucleic acid target molecules. This binding reaction enables their application as biorecognition elements in biosensors and assays. As antibiotic residues pose a problem contributing to the emergence of antibiotic-resistant pathogens and thereby reducing the eff...
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ژورنال
عنوان ژورنال: Pharmaceutica Analytica Acta
سال: 2012
ISSN: 2153-2435
DOI: 10.4172/2153-2435.1000193